Case Study #3 - Indication Landscaping and Visualisation to Update Target Product Profiles (TPP)

• A large pharma company’s clinical development team was struggling to get a holistic view of the company’s pipeline assets’ positioning in a specific oncology indication landscape. They also wanted to update the TPP of all SOCs in the many patient populations in this given indication. Lastly, they wanted to have a visual representation of the landscape.
• Conducted comprehensive indication landscaping and literature review to update standard-of-care benchmarks and efficacy hurdles for 30+ internal pipeline trials in the indication of interest.
• Delivered an executive-level PowerPoint report featuring visual tumour maps illustrating lines of therapy, patient segmentation, updated comparator SOCs and updated efficacy hurdles.
• Synthesised complex clinical efficacy data into a structured summary deck, clarifying competitive positioning across patient subpopulations.
• SOC tumour landscaping and visualisation output supported internal trial design (3 new opportunity study designs) and BD opportunity discussions, leading to requests for replicating this work for 2 additional indications and a presentation at company-wide forums.
• Allowed the RWE team to accurately understand the treatment landscapes and to build patient population models.